Adinizer is an FDA-cleared, Class II medical device that processes adipose (fat) tissue through precision, blade-based resizing. Its ultra-sharp discs cut tissue cleanly—preserving stromal cells, extracellular matrix (ECM), and regenerative factors for high-quality grafts and stromal tissue matrices.

Adinizer cuts, not crushes, fat. This means:

• Cleaner processing: Razor-edged blades minimize damage versus blunt pressure systems.
  
• Lower pressure: Multi-blade design reduces shear stress.
  
• Higher viability: >90 % live cell yield with intact stromal cells, ECM, and secretomes.
  
• Controlled sizing: Create macro-, micro-, and nanofat or stromal concentrates with one workflow.

Adinizer supports both structural and regenerative applications, including:

• Facial, breast, and body fat grafting
  
• Scar and skin rejuvenation (nanofat)
  
• Wound care and fibrosis (stromal tissue matrices)
  
• Orthobiologics for joints and tendons
  
• Hair and scalp restoration
  
  Fat is an abundant, autologous, regenerative material ideal for these uses.

Published data show:

• >90 % cell viability
  
• Preserved ECM and stromal niches
  
• High MSC marker expression (CD73⁺, CD90⁺, CD105⁺)
  
• Detectable regenerative factors (VEGF, NGF, IL-10, TGF-β)
  
  Clinically, this means longer-lasting grafts, improved texture, and enhanced tissue healing.

Yes. Peer-reviewed studies confirm higher viability, lower tissue damage, and stronger secretome profiles compared with emulsification or bead systems. References and data are available upon request, info@theadinizer.com. Reference Key (Peer-Reviewed Works)

1.  Copcu HE, Oztan S. New Mechanical Fat Separation Technique: ARAT & MEST. Aesthet
Surg J Open Forum. 2020.

2.  Copcu HE. Indication-Based
Protocols With Different Solutions for MEST. Scars Burn Heal. 2022.

3.   Copcu HE. Supercharged
Mechanical Stromal-Cell Transfer (PPP). Plast Reconstr Surg Glob Open.
2021.

4.  Copcu HE. Three
Delivery Methods of Stromal Aggregates. Plast Reconstr Surg Glob Open. 2021.

5.   Copcu HE. Diet
Fat-Free Fat Grafting. 2021.

6.   Copcu HE. A New Classification System for Adipose-Derived Stromal Cell Systems. 2022.

7.  Asian Hair 2025 Comparative Trial. Device Comparison of Adinizer vs Emulsification.
2025.

8. Sowa Y, et al. Micronized Cellular Adipose Matrix (MCAM) vs Enzymatic SVF. Tissue Cell. 2024.

9.    Sasaki GH. Stromal Cell & PRP Dosing in Facelift. Aesthet Surg J Open Forum. 2025.
10.  Behn A, et al. Secretome Comparison (Adinizer vs Lipocube). Front Cell Dev
Biol. 2025.

11.  Namgoong S, et al. Adinizer STM in Diabetic Foot Ulcers: RCT. J Clin Med. 2022.

12.  Copcu HE. DPAT+ Exosome Autologization. 2023.

13.  Trivisonno A, Alexander RW, et al. Minimal Manipulation: tSVF vs cSVF. Stem Cells
Transl Med. 2019.
14.  Hayward WA, et al. Syringe Pressure Study. Scand J Plast Reconstr Surg Hand Surg.
2011.

15.  La Padula S, etal. Nanofat Applications Review. J Clin Med. 2023.
16.  Herbert D, et al. Secretome Profiles of Adipose-Derived Cells. Stem Cells Dev.2012.
17.  Chen X, et al. Nanofat Viability Under Shear Stress. J Plast Surg Hand Surg.
2020.

Yes. Adinizer is a 510(k)-cleared, Class II device in the U.S. and is CE- and KFDA-approved internationally. It performs only mechanical resizing—no enzymes or additives—meeting minimal-manipulation standards.

Adinizer creates new revenue opportunities through fat-based aesthetic and regenerative services, offers fast processing, and supports patient retention through repeat biostimulatory treatments.

Plastic surgeons, facial plastic specialists, dermatologists, orthobiologic, and gynecologic clinicians worldwide use Adinizer for both aesthetic and regenerative protocols.

Yes. Adinizer connects with standard harvest cannulas, syringes, and centrifuges. Training videos, guides, and workshops are available.

Stepped-blade discs (4000→ 2400 → 1200 → 600 → 400 µm and smaller) deliver tailored outputs from macrofat to nanofat. Each sterile, single-use kit connects via standard luer-lock syringes—simple, efficient, and compatible with most systems.

Yes. Adinizer operates entirely within a closed syringe loop, maintaining sterility and compliance for autologous, minimally manipulated tissue.

Structural grafts: 3–5 passes in seconds.

Stromal tissue matrices: <10 minutes post-purification.

Quick, efficient, and console-free.